Singlet oxygen stimulates mitochondrial bioenergetics in brain cells

Oxygen, in form of reactive oxygen species (ROS), has been shown to participate oxidative stress, one the major triggers for pathology, but also is a main contributor physiological processes. Recently, it was found that 1267 nm irradiation can produce singlet without photosensitizers. We used this phenomenon study effect laser-generated on oxygen-dependent processes, mitochondrial energy metabolism. have laser-induced generation 1O2 neurons and astrocytes led increase membrane potential, activation NADH- FADH-dependent respiration, importantly, increased rate maximal respiration isolated mitochondria. The stimulated production ATP these cells. Thus, we generated by laser pulse works as an activator brain.